Proteome changes of plasma-derived extracellular vesicles in patients with myelodysplastic syndrome.

ABSTRACT:

Background

Extracellular vesicles are released into body fluids from the majority of, if not all, cell types. Because their secretion and specific cargo (e.g., proteins) varies according to pathology, extracellular vesicles may prove a rich source of biomarkers. However, their biological and pathophysiological functions are poorly understood in hematological malignancies.

Objective

Here, we investigated proteome changes in the exosome-rich fraction of the plasma of myelodysplastic syndrome patients and healthy donors.

Methods

Exosome-rich fraction of the plasma was isolated using ExoQuick™: proteomes were compared and statistically processed; proteins were identified by nanoLC-MS/MS and verified using the ExoCarta and QuickGO databases. Mann-Whitney and Spearman analy

SUBMITTER: Pecankova K 

PROVIDER: S-EPMC8746746 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature