A novel theoretical framework for simultaneous measurement of excitatory and inhibitory conductances.

ABSTRACT: The firing of neurons throughout the brain is determined by the precise relations between excitatory and inhibitory inputs, and disruption of their balance underlies many psychiatric diseases. Whether or not these inputs covary over time or between repeated stimuli remains unclear due to the lack of experimental methods for measuring both inputs simultaneously. We developed a new analytical framework for instantaneous and simultaneous measurements of both the excitatory and inhibitory neuronal inputs during a single trial under current clamp recording. This can be achieved by injecting a current composed of two high frequency sinusoidal components followed by analytical extraction of the conductances. We demonstrate the ability of this method to measure both inputs in a single trial under

SUBMITTER: Muller-Komorowska D 

PROVIDER: S-EPMC8746761 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature