Neisseria gonorrhoeae subverts formin-dependent actin polymerization to colonize human macrophages.

ABSTRACT: Dynamic reorganization of the actin cytoskeleton dictates plasma membrane morphogenesis and is frequently subverted by bacterial pathogens for entry and colonization of host cells. The human-adapted bacterial pathogen Neisseria gonorrhoeae can colonize and replicate when cultured with human macrophages, however the basic understanding of how this process occurs is incomplete. N. gonorrhoeae is the etiological agent of the sexually transmitted disease gonorrhea and tissue resident macrophages are present in the urogenital mucosa, which is colonized by the bacteria. We uncovered that when gonococci colonize macrophages, they can establish an intracellular or a cell surface-associated niche that support bacterial replication independently. Unlike other intracellular bacterial pathogens, which

SUBMITTER: Ivanov SS 

PROVIDER: S-EPMC8746766 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature