Molecular and epidemiological characterization of recurrent Mycobacterium ulcerans infections in Benin.

ABSTRACT:

Background

Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans, an environmental mycobacterium. Although transmission of M. ulcerans remains poorly understood, the main identified risk factor for acquiring Buruli ulcer is living in proximity of potentially contaminated water sources. Knowledge about the clinical features of Buruli ulcer and its physiopathology is increasing, but little is known about recurrence due to reinfection.

Methodology/principal findings

We describe two patients with Buruli ulcer recurrence due to reinfection with M. ulcerans, as demonstrated by comparisons of DNA from the strains isolated at the time of the first diagnosis and at recurrence. Based on the spatial distribution of M. ulcerans genotypes in this region and a deta

SUBMITTER: Gnimavo R 

PROVIDER: S-EPMC8746791 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature