Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage.

ABSTRACT: Solar ultraviolet radiation (UVR) is a major source of skin damage, resulting in inflammation, premature ageing, and cancer. While several UVR-induced changes, including extracellular matrix reorganisation and epidermal DNA damage, have been documented, the role of different fibroblast lineages and their communication with immune cells has not been explored. We show that acute and chronic UVR exposure led to selective loss of fibroblasts from the upper dermis in human and mouse skin. Lineage tracing and in vivo live imaging revealed that repair following acute UVR is predominantly mediated by papillary fibroblast proliferation and fibroblast reorganisation occurs with minimal migration. In contrast, chronic UVR exposure led to a permanent loss of papillary fibroblasts, with expansion of fi

SUBMITTER: Rognoni E 

PROVIDER: S-EPMC8747514 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature