The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors.

ABSTRACT: Here, we propose and study several types of quartz surface coatings designed for the high-performance sorption of biomolecules and their subsequent detection by a photonic crystal surface mode (PC SM) biosensor. The deposition and sorption of biomolecules are revealed by analyzing changes in the propagation parameters of optical modes on the surface of a photonic crystal (PC). The method makes it possible to measure molecular and cellular affinity interactions in real time by independently recording the values of the angle of total internal reflection and the angle of excitation of the surface wave on the surface of the PC. A series of dextrans with various anchor groups (aldehyde, carboxy, epoxy) suitable for binding with bioligands have been studied. We have carried out comparative exper

SUBMITTER: Sizova S 

PROVIDER: S-EPMC8747551 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature