Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients.

ABSTRACT:

Background/aims

Coronavirus disease 2019 (COVID-19) is associated with acute respiratory syndrome. The mechanisms underlying the different degrees of pneumonia severity in patients with COVID-19 remain elusive. This study provides evidence that COVID-19 is associated with eosinophil-mediated inflammation.

Methods

We performed a retrospective case series of three patients with laboratory and radiologically confirmed COVID-19 pneumonia admitted to Chosun University Hospital. Demographic and clinical data on inflammatory cell lung infiltration and cytokine levels in patients with COVID-19 were collected.

Results

Cytological analysis of sputum, tracheal aspirates, and bronchoalveolar lavage fluid (BALF) samples from all three patients revealed massive infiltration of poly

SUBMITTER: Kim DM 

PROVIDER: S-EPMC8747909 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature