Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population.

ABSTRACT: Host genetic factors have been shown to play a role in SARs-CoV-2 infection in diverse populations. However, the genetic landscape differs among various ethnicities; therefore, we explored the host genetic factors associated with COVID-19 disease susceptivity and disease severity in a Thai population. We recruited and genotyped 212 unrelated COVID-19 Thai patients and 36 controls using Axiom^TM Human Genotyping SARs-COV-2 array, including 847,384 single nucleotide polymorphisms related to SARs-COV-2 pathogenesis, immune response, and related comorbidity No SNPs passed the genome-wide significance threshold of p value <1 × 10^-8. However, with a threshold of p value <1 × 10^-5, a locus on chromosome 5q32 was found to have a suggestive association with COVID-19

SUBMITTER: Chamnanphon M 

PROVIDER: S-EPMC8748005 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature