Analysis of dynamic molecular networks: the progression from colorectal adenoma to cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the deadliest cancers worldwide. It is the fourth most deadly cancer in the world with nearly 900,000 people die every year, the progression of polyps into cancer as one of its most common developmental pathways.

Methods

This study obtained gene chip data collections from the Gene Expression Omnibus for colorectal adenoma (GSE8671) and colorectal cancer (GSE32323). Differentially expressed genes (DEGs) in normal tissue and different stages of CRC were analyzed for clustering, comparison, and visualization using R software. The Cytoscape plugin DyNetViewer was used to construct a dynamic protein-protein interaction network. Subsequently, through the Database for Annotation, Visualization and Integrated Discovery, the DEGs were func

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8748073 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature