Multi-omics-based identification of atopic dermatitis target genes and their potential associations with metabolites and miRNAs.

ABSTRACT: Atopic dermatitis (AD), or atopic eczema, is one of the most common inflammatory skin diseases with up to 10% prevalence in adults, and approximately 15-20% in children in industrialized countries. As a result, there is an unmet need for faster, safer, and effective treatments for AD. AD pathogenesis represents a complex interplay between multiple factors, such as environmental factors or stimuli, genetic factors, immune dysfunctions. However, although multi-omics label studies have been very useful in understanding the pathophysiological mechanisms of AD and its clinical manifestations, there have been very few studies that integrate different labels of omics data. Here, we attempted to integrate gene expression and metabolomics datasets from multiple different publicly available AD cohor

SUBMITTER: Acharjee A 

PROVIDER: S-EPMC8748113 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature