Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance.

ABSTRACT:

Background

Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms.

Methods

Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by

SUBMITTER: Contreras-Rodriguez O 

PROVIDER: S-EPMC8748191 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature