The postnatal leptin surge in mice is variable in both time and intensity and reflects nutritional status.

ABSTRACT:

Background/objectives

The murine postnatal leptin surge occurs within the first 4 weeks of life and is critical for neuronal projection development within hypothalamic feeding circuits. Here we describe the influence of nutritional status on the timing and magnitude of the postnatal leptin surge in mice.

Methods

Plasma leptin concentrations were measured 1-3 times per week for the first 4 weeks of life in C57BL/6J pups reared in litters adjusted to 3 (small), 7-8 (normal), or 11-12 (large) pups per dam fed breeder chow or raised in litters of 7-8 by dams fed high-fat diet (HFD) ad libitum starting either prior to conception or at parturition.

Results

Mice raised in small litters become fatter than pups raised in either normal or large litters. The leptin surge in smal

SUBMITTER: Skowronski AA 

PROVIDER: S-EPMC8748198 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature