Circulating naive and effector memory T cells correlate with prognosis in head and neck squamous cell carcinoma.

ABSTRACT: T-cell memory is an important mechanism for long-term protection against diverse pathogens. Generation and persistence of memory T cells are vital components of anti-tumor immunity, given their ability to persist for prolonged durations, as well as activate and migrate rapidly. In the present study, we investigated the clinical and prognostic significance of T-cell subsets in the peripheral circulation of patients with head and neck squamous cell carcinoma (HNSCC). Moreover, we calculated the enrichment scores of T-cell subsets in primary tumor tissues and compared their clinical characteristics using a public database. Multivariate survival analyses of circulating T-cell parameters revealed that clinical parameters, except M factor, were not independent prognostic factors, whereas proport

SUBMITTER: Takahashi H 

PROVIDER: S-EPMC8748237 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature