Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model.

ABSTRACT:

Purpose

Compared with photon cranial radiation therapy (X-CRT), proton cranial radiation therapy (P-CRT) offers potential advantages in limiting radiation-induced sequalae in the treatment of pediatric brain tumors. This study aims to identify cognitive, functional magnetic resonance and positron emission tomography imaging markers and molecular differences between the radiation modalities.

Methods and materials

Juvenile rats received a single faction of 10 Gy (relative biological effectiveness-weighted dose) delivered with 6 MV X-CRT or at the midspread out Bragg peak of a 100 MeV P-CRT beam. At 3, 6, and 12 months post-CRT, executive function was measured using 5-choice serial reaction time task. At ∼12 months post-CRT, animals were imaged with ¹⁸F-Flurodeoxy-gl

SUBMITTER: Tang TT 

PROVIDER: S-EPMC8748279 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature