Determination of lithium in human serum by isotope dilution atomic absorption spectrometry.

ABSTRACT: The therapeutic dose of lithium (Li) compounds, which are widely used for the treatment of psychiatric and hematologic disorders, is close to its toxic level; therefore, drug monitoring protocols are mandatory. Herein, we propose a fast, simple, and low-cost analytical procedure for the traceable determination of Li concentration in human serum, based on the monitoring of the Li isotope dilution through the partially resolved isotope shift in its electronic transition around 670.80 nm using a commercially available high-resolution continuum source graphite furnace atomic absorption spectrometer. With this technique, serum samples only require acidic digestion before analysis. The procedure requires three measurements-an enriched ⁶Li spike, a mixture of a certified standard solut

SUBMITTER: Winckelmann A 

PROVIDER: S-EPMC8748318 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature