Age-dependent decline of copper clearance at the blood-cerebrospinal fluid barrier.

ABSTRACT: The homeostasis of copper (Cu) in the central nervous system is regulated by the blood-brain barrier and blood-cerebrospinal (CSF) barrier (BCB) in the choroid plexus. While proteins responsible for Cu uptake, release, storage and intracellular trafficking exist in the choroid plexus, the influence of age on Cu clearance from the CSF via the choroid plexus and how Cu transporting proteins contribute to the process are unelucidated. This study was designed to test the hypothesis that the aging process diminishes Cu clearance from the CSF of rats by disrupting Cu transporting proteins in the choroid plexus. Data from ventriculo-cisternal perfusion experiments demonstrated greater ⁶⁴Cu radioactivity in the CSF effluents of older rats (18 months) compared to younger (1 month) and ad

SUBMITTER: Liu LL 

PROVIDER: S-EPMC8748412 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature