A Novel Role for RNF126 in the Promotion of G2 Arrest via Interaction With 14-3-3σ.

ABSTRACT:

Purpose

Cell cycle checkpoints and DNA repair are important for cell survival after exogenous DNA damage. Both rapid blockage of G2 to M phase transition in the cell cycle and the maintenance of relatively slow G2 arrest are critical to protect cells from lethal ionizing radiation (IR). Checkpoint kinase 1 is pivotal in blocking the transition from G2 to M phases in response to IR. The 14-3-3σ protein is important for IR-induced G2 arrest maintenance in which p53-dependent 14-3-3σ transcription is involved. It has been demonstrated that Ring finger protein 126 (RNF126), an E3 ligase, is required to upregulate checkpoint kinase 1 expression. Thus, our goal was to study the role of RNF126 in the G2/M phase checkpoint.

Methods and materials

The transition from G2 to M phases an

SUBMITTER: Fa P 

PROVIDER: S-EPMC8748417 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature