Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies-in silico analysis.

ABSTRACT:

Background

Tumor necrosis factor alpha (TNFA) is an important cytokine that influences multiple biological processes. It is one of the key mediators of acute and chronic systemic inflammatory reactions and plays a central role in several autoimmune diseases. A number of approved monoclonal antibodies (mAbs) are widely used to subside these autoimmune diseases. However, there is a high rate of non-responsiveness to treatments with these mAbs. Therefore, it is important to be able to predict responses of the patients in an individualistic manner to these therapeutic antibodies before administration. In the present study, we used in silico tools to explore the effects of missense variants in the respective epitopes of four therapeutic anti-TNFA mAbs-adalimumab (ADA), certolizumab pego

SUBMITTER: Ahsan T 

PROVIDER: S-EPMC8748575 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature