Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression.

ABSTRACT: Ketamine has rapid and sustained antidepressant effects in patients with treatment-resistant depression (TRD). However, the underlying mechanisms of action are not well understood. There is increasing evidence that TRD is associated with a pro-inflammatory state and that ketamine may inhibit inflammatory processes. We thus investigated whole blood transcriptional profiles related to TRD and gene expression changes associated with treatment response to ketamine. Whole blood was collected at baseline (21 healthy controls [HC], 26 patients with TRD) and then again in patients with TRD 24 hours following a single intravenous infusion of ketamine (0.5 mg/kg). We performed RNA-sequencing and analyzed (a) baseline transcriptional profiles between patients with TRD and HC, (b) responders vs. non-r

SUBMITTER: Cathomas F 

PROVIDER: S-EPMC8748646 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature