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Lipidomic profiling of human serum enables detection of pancreatic cancer.

ABSTRACT: Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body fluids may improve the survival time prognosis of patients, who are often diagnosed too late at an incurable stage. Several studies report the dysregulation of lipid metabolism in tumor cells, suggesting that changes in the blood lipidome may accompany tumor growth. Here we show that the comprehensive mass spectrometric determination of a wide range of serum lipids reveals statistically significant differences between pancreatic cancer patients and healthy controls, as visualized by multivariate data analysis. Three phases of biomarker discovery research (discovery, qualification, and verification) are applied for 830 samples in total, which shows the dysregulation of some very long chain sphingomyelins, ceramides, and (lyso)phosphatidylcholines. The sensitivity and specificity to diagnose pancreatic cancer are over 90%, which outperforms CA 19-9, especially at an early stage, and is comparable to established diagnostic imaging methods. Furthermore, selected lipid species indicate a potential as prognostic biomarkers.

SUBMITTER: Wolrab D

PROVIDER: S-EPMC8748654 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Lipidomic profiling of human serum enables detection of pancreatic cancer.

Wolrab Denise D Jirásko Robert R Cífková Eva E Höring Marcus M Mei Ding D Chocholoušková Michaela M Peterka Ondřej O Idkowiak Jakub J Hrnčiarová Tereza T Kuchař Ladislav L Ahrends Robert R Brumarová Radana R Friedecký David D Vivo-Truyols Gabriel G Škrha Pavel P Škrha Jan J Kučera Radek R Melichar Bohuslav B Liebisch Gerhard G Burkhardt Ralph R Wenk Markus R MR Cazenave-Gassiot Amaury A Karásek Petr P Novotný Ivo I Greplová Kristína K Hrstka Roman R Holčapek Michal M

Nature communications 20220110 1

Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body fluids may improve the survival time prognosis of patients, who are often diagnosed too late at an incurable stage. Several studies report the dysregulation of lipid metabolism in tumor cells, suggesting that changes in the blood lipidome may accompany tumor growth. Here we show that the comprehensive mass spectrometric determination of a wide range of serum lipids reveals statistically significant differences ...[more]

PMID: 35013261

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Lipidomic profiling of human serum enables detection of pancreatic cancer.

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Lipidomic profiling of human serum enables detection of pancreatic cancer.

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