RNA-binding protein p54^nrb/NONO potentiates nuclear EGFR-mediated tumorigenesis of triple-negative breast cancer.

ABSTRACT: Nuclear-localized epidermal growth factor receptor (EGFR) highly correlates with the malignant progression and may be a promising therapeutic target for breast cancer. However, molecular mechanisms of nuclear EGFR in triple-negative breast cancer (TNBC) have not been fully elucidated. Here, we performed gene-annotation enrichment analysis for the interactors of nuclear EGFR and found that RNA-binding proteins (RBPs) were closely associated with nuclear EGFR. We further demonstrated p54^nrb/NONO, one of the RBPs, significantly interacted with nuclear EGFR. NONO was upregulated in 80 paired TNBC tissues and indicated a poor prognosis. Furthermore, NONO knockout significantly inhibited TNBC proliferation in vitro and in vivo. Mechanistically, NONO increased the stability of nuclear

SUBMITTER: Shen M 

PROVIDER: S-EPMC8748691 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature