Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.

ABSTRACT: Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developme

SUBMITTER: Nomura T 

PROVIDER: S-EPMC8748702 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature