Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.

ABSTRACT: Myocardial infarction causes 7.3 million deaths worldwide, mostly for fibrillation that electrically originates from the damaged areas of the left ventricle. Conventional cardiac bypass graft and percutaneous coronary interventions allow reperfusion of the downstream tissue but do not counteract the bioelectrical alteration originated from the infarct area. Genetic, cellular, and tissue engineering therapies are promising avenues but require days/months for permitting proper functional tissue regeneration. Here we engineered biocompatible silicon carbide semiconductive nanowires that synthetically couple, via membrane nanobridge formations, isolated beating cardiomyocytes over distance, restoring physiological cell-cell conductance, thereby permitting the synchronization of bioelectrical a

SUBMITTER: Lagonegro P 

PROVIDER: S-EPMC8748722 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature