Ontology highlight
ABSTRACT:
SUBMITTER: Santa Cruz Garcia AB
PROVIDER: S-EPMC8748731 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Santa Cruz Garcia Ana Beatriz AB Schnur Kevin P KP Malik Asrar B AB Mo Gary C H GCH
Nature communications 20220110 1
Gasdermin D forms large, ~21 nm diameter pores in the plasma membrane to drive the cell death program pyroptosis. These pores are thought to be permanently open, and the resultant osmotic imbalance is thought to be highly damaging. Yet some cells mitigate and survive pore formation, suggesting an undiscovered layer of regulation over the function of these pores. However, no methods exist to directly reveal these mechanistic details. Here, we combine optogenetic tools, live cell fluorescence bios ...[more]