Esophageal regeneration following surgical implantation of a tissue engineered esophageal implant in a pediatric model.

ABSTRACT: Diseases of the esophagus, damage of the esophagus due to injury or congenital defects during fetal esophageal development, i.e., esophageal atresia (EA), typically require surgical intervention to restore esophageal continuity. The development of tissue engineered tubular structures would improve the treatment options for these conditions by providing an alternative that is organ sparing and can be manufactured to fit the exact dimensions of the defect. An autologous tissue engineered Cellspan Esophageal Implant^TM (CEI) was surgically implanted into piglets that underwent surgical resection of the esophagus. Multiple survival time points, post-implantation, were analyzed histologically to understand the tissue architecture and time course of the regeneration process. In additio

SUBMITTER: Sundaram S 

PROVIDER: S-EPMC8748753 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature