The m⁶A methyltransferase METTL3 regulates muscle maintenance and growth in mice.

ABSTRACT: Skeletal muscle serves fundamental roles in organismal health. Gene expression fluctuations are critical for muscle homeostasis and the response to environmental insults. Yet, little is known about post-transcriptional mechanisms regulating such fluctuations while impacting muscle proteome. Here we report genome-wide analysis of mRNA methyladenosine (m⁶A) dynamics of skeletal muscle hypertrophic growth following overload-induced stress. We show that increases in METTL3 (the m⁶A enzyme), and concomitantly m⁶A, control skeletal muscle size during hypertrophy; exogenous delivery of METTL3 induces skeletal muscle growth, even without external triggers. We also show that METTL3 represses activin type 2 A receptors (ACVR2A) synthesis, blunting activation of anti-

SUBMITTER: Petrosino JM 

PROVIDER: S-EPMC8748755 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature