The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans.

ABSTRACT: Defense against intracellular infection has been extensively studied in vertebrate hosts, but less is known about invertebrate hosts; specifically, the transcription factors that induce defense against intracellular intestinal infection in the model nematode Caenorhabditis elegans remain understudied. Two different types of intracellular pathogens that naturally infect the C. elegans intestine are the Orsay virus, which is an RNA virus, and microsporidia, which comprise a phylum of fungal pathogens. Despite their molecular differences, these pathogens induce a common host transcriptional response called the intracellular pathogen response (IPR). Here we show that zip-1 is an IPR regulator that functions downstream of all known IPR-activating and regulatory pathways. zip-1 encodes a putativ

SUBMITTER: Lazetic V 

PROVIDER: S-EPMC8748929 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature