Agr Quorum Sensing influences the Wood-Ljungdahl pathway in Clostridium autoethanogenum.

ABSTRACT: Acetogenic bacteria are capable of fermenting CO₂ and carbon monoxide containing waste-gases into a range of platform chemicals and fuels. Despite major advances in genetic engineering and improving these biocatalysts, several important physiological functions remain elusive. Among these is quorum sensing, a bacterial communication mechanism known to coordinate gene expression in response to cell population density. Two putative agr systems have been identified in the genome of Clostridium autoethanogenum suggesting bacterial communication via autoinducing signal molecules. Signal molecule-encoding agrD1 and agrD2 genes were targeted for in-frame deletion. During heterotrophic growth on fructose as a carbon and energy source, single deletions of either gene did not produce an ob

SUBMITTER: Piatek P 

PROVIDER: S-EPMC8748961 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature