MicroRNA-30d target TIMP3 induces pituitary tumor cell growth and invasion.

ABSTRACT:

Background

As one of the most common intracranial tumors, pituitary adenomas, especially the Cushing's disease subtype, have been studied for many years. However, at present, effective methods for the early diagnosis of pituitary adenomas are very limited, especially for subtypes such as Cushing's disease. Therefore, it is of urgent importance to find effective molecular targets to develop new diagnostic and therapeutic methods for pituitary adenomas.

Methods

We showed the abnormally high expression of miR-30d in pituitary adenomas by analyzing data in the Gene Expression Omnibus (GEO) database and revealed a novel molecular mechanism of miR-30d in regulating the proliferation and invasion of a pituitary adenoma cell line (AtT-20). Cell culture and transfection, and RNA inte

SUBMITTER: Sun B 

PROVIDER: S-EPMC8749101 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature