Epicardial adipose tissue thickness is associated with increased COVID-19 severity and mortality.

ABSTRACT:

Background

Increased adiposity and visceral obesity have been linked to adverse COVID-19 outcomes. The amount of epicardial adipose tissue (EAT) may have relevant implications given its proximity to the heart and lungs. Here, we explored the role of EAT in increasing the risk for COVID-19 adverse outcomes.

Methods

We included 748 patients with COVID-19 attending a reference center in Mexico City. EAT thickness, sub-thoracic and extra-pericardial fat were measured using thoracic CT scans. We explored the association of each thoracic adipose tissue compartment with COVID-19 mortality and severe COVID-19 (defined as mortality and need for invasive mechanical ventilation), according to the presence or absence of obesity. Mediation analyses evaluated the role of EAT in facilitati

SUBMITTER: Mehta R 

PROVIDER: S-EPMC8749108 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature