Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Currently there is a paucity of clinically available regenerative therapies for stroke. Extracellular vesicles (EV) have been investigated for their potential as modulators of regeneration in the poststroke brain. This systematic review and meta-analysis aims to provide a summary of the efficacy of therapeutic EVs in preclinical stroke models, to inform future research in this emerging field.

Methods

Studies were identified by a comprehensive literature search of two online sources and subsequent screening. Studies using lesion volume or neurological score as outcome measures were included. Standardised mean difference (SMD) and 95% CIs were calculated using a restricted maximum likelihood random effects model. Publication bias was assessed with Egger's regression

SUBMITTER: Thomas JM 

PROVIDER: S-EPMC8749279 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature