Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.

ABSTRACT:

Objectives

Systemic endothelial activation may contribute to sepsis-associated organ injury, including acute respiratory distress syndrome. We hypothesized that children with extrapulmonary sepsis with versus without acute respiratory distress syndrome would have plasma biomarkers indicative of increased endothelial activation and that persistent biomarker changes would be associated with poor outcome.

Design

Observational cohort.

Setting

Academic PICU.

Patients

Patients less than 18 years old with sepsis from extrapulmonary infection with (n = 46) or without (n = 54) acute respiratory distress syndrome and noninfected controls (n = 19).

Interventions

None.

Measurements and main results

Endothelial (angiopoietin-1, angiopoietin-2, tyrosine kinase

SUBMITTER: Whitney JE 

PROVIDER: S-EPMC8749338 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature