Disentangling the Evolutionary History of Feo, the Major Ferrous Iron Transport System in Bacteria.

ABSTRACT: Iron acquisition is essential for almost all living organisms. In certain environments, ferrous iron is the most prevalent form of this element. Feo is the most widespread system for ferrous iron uptake in bacteria and is critical for virulence in some species. The canonical architecture of Feo consists of a large transmembrane nucleoside triphosphatase (NTPase) protein, FeoB, and two accessory cytoplasmic proteins, FeoA and FeoC. The role of the latter components and the mechanism by which Feo orchestrates iron transport are unclear. In this study, we conducted a comparative analysis of Feo protein sequences to gain insight into the evolutionary history of this transporter. We identified instances of how horizontal gene transfer contributed to the evolution of Feo. Also, we found that Feo

SUBMITTER: Gomez-Garzon C 

PROVIDER: S-EPMC8749426 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature