Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin.

ABSTRACT: Typhoid toxin is an A₂B₅ protein toxin and an important virulence factor for the human-adapted bacterial pathogen Salmonella enterica serovar Typhi, the causative agent of typhoid fever. Typhoid toxin contains two enzymatic subunits, PltA and CdtB, which dock onto a pentameric delivery platform composed of the protein PltB. It was recently reported that the same enzymatic subunits can assemble with a different delivery platform composed of the protein PltC, forming a distinct version of typhoid toxin. However, the differences in structure and receptor specificity between the PltC and PltB typhoid toxins remain unknown. Here, we determined atomic-level structures of the pentameric PltC subunit, the fully assembled PltC typhoid toxin, and the PltC pentamers in complex w

SUBMITTER: Liu X 

PROVIDER: S-EPMC8749428 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature