Task-induced subjective fatigue and resting-state striatal connectivity following traumatic brain injury.

ABSTRACT:

Background

People with traumatic brain injury (TBI) often experience fatigue, but an understanding of the neural underpinnings of fatigue following TBI is still lacking. This study used resting-state functional magnetic resonance imaging (rs-fMRI) to examine associations between functional connectivity (FC) changes and task-induced changes in subjective fatigue in people with moderate-severe TBI.

Methods

Sixteen people with moderate-severe TBI and 17 matched healthy controls (HC) performed an adaptive N-back task (working memory task) to induce cognitive fatigue. Before and after the task they rated their state fatigue level and underwent rs-fMRI. Seed-to-voxel analyses with seeds in areas involved in cognitive fatigue, namely the striatum and default mode network (DMN) incl

SUBMITTER: Bruijel J 

PROVIDER: S-EPMC8749448 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature