Proton Minibeam Radiation Therapy and Arc Therapy: Proof of Concept of a Winning Alliance.

ABSTRACT: (1) Background: Proton Arc Therapy and Proton Minibeam Radiation Therapy are two novel therapeutic approaches with the potential to lower the normal tissue complication probability, widening the therapeutic window for radioresistant tumors. While the benefits of both modalities have been individually evaluated, their combination and its potential advantages are being assessed in this proof-of-concept study for the first time. (2) Methods: Monte Carlo simulations were employed to evaluate the dose and LET distributions in brain tumor irradiations. (3) Results: a net reduction in the dose to normal tissues (up to 90%), and the preservation of the spatial fractionation of the dose were achieved for all configurations evaluated. Additionally, Proton Minibeam Arc Therapy (pMBAT) reduces the vol

SUBMITTER: Ortiz R 

PROVIDER: S-EPMC8749801 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature