Orai2 Modulates Store-Operated Ca²⁺ Entry and Cell Cycle Progression in Breast Cancer Cells.

ABSTRACT: Breast cancer is a heterogeneous disease from the histological and molecular expression point of view, and this heterogeneity determines cancer aggressiveness. Store-operated Ca²⁺ entry (SOCE), a major mechanism for Ca²⁺ entry in non-excitable cells, is significantly remodeled in cancer cells and plays an important role in the development and support of different cancer hallmarks. The store-operated CRAC (Ca²⁺ release-activated Ca²⁺) channels are predominantly comprised of Orai1 but the participation of Orai2 and Orai3 subunits has been reported to modulate the magnitude of Ca²⁺ responses. Here we provide evidence for a heterogeneous expression of Orai2 among different breast cancer cell lines. In the HER2 and triple negative breast ca

SUBMITTER: Sanchez-Collado J 

PROVIDER: S-EPMC8749845 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature