Risk Stratification and Treatment in Smoldering Multiple Myeloma.

ABSTRACT: Smoldering multiple myeloma is a heterogeneous asymptomatic precursor to multiple myeloma. Since its identification in 1980, risk stratification models have been developed using two main stratification methods: clinical measurement-based and genetics-based. Clinical measurement models can be subdivided in three types: baseline measurements (performed at diagnosis), evolving measurements (performed over time during follow-up appointments), and imaging (for example, magnetic resonance imaging). Genetic approaches include gene expression profiling, DNA/RNA sequencing, and cytogenetics. It is important to accurately distinguish patients with indolent disease from those with aggressive disease, as clinical trials have shown that patients designated as "high-risk of progression" have improved ou

SUBMITTER: Lussier T 

PROVIDER: S-EPMC8750018 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature