N-Glycosylation Facilitates 4-1BB Membrane Localization by Avoiding Its Multimerization.

ABSTRACT: Leveraging the T cell immunity against tumors represents a revolutionary type of cancer therapy. 4-1BB is a well-characterized costimulatory immune receptor existing on activated T cells and mediating their proliferation and cytotoxicity under infectious diseases and cancers. Despite the accumulating interest in implementing 4-1BB as a therapeutic target for immune-related disorders, less is known about the pattern of its intracellular behaviors and regulations. It has been previously demonstrated that 4-1BB is heavily modified by N-glycosylation; however, the biological importance of this modification lacks detailed elucidation. Through biochemical, biophysical, and cell-biological approaches, we systematically evaluated the impact of N-glycosylation on the ligand interactio

SUBMITTER: Sun R 

PROVIDER: S-EPMC8750214 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature