The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer.

ABSTRACT: In the past decade, cell cycle regulators have extended their canonical role in cell cycle progression to the regulation of various cellular processes, including cellular metabolism. The regulation of metabolism is intimately connected with the function of autophagy, a catabolic process that promotes the efficient recycling of endogenous components from both extrinsic stress, e.g., nutrient deprivation, and intrinsic sub-lethal damage. Mediating cellular homeostasis and cytoprotection, autophagy is found to be dysregulated in numerous pathophysiological contexts, such as cancer. As an adaptative advantage, the upregulation of autophagy allows tumor cells to integrate stress signals, escaping multiple cell death mechanisms. Nevertheless, the precise role of autophagy during tumor developmen

SUBMITTER: Ziegler DV 

PROVIDER: S-EPMC8750274 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature