Smaller visual arrays are harder to integrate in schizophrenia: Evidence for impaired lateral connections in early vision.

ABSTRACT: Long-range horizontal connections in early vision undergird a well-studied "collinear facilitation" effect, wherein a central low-contrast target becomes more detectable when flanked by collinear elements. Collinear facilitation is weaker in schizophrenia. Might lateral connections be responsible? To consider the possibility, we had 38 schizophrenia patients and 49 well-matched healthy controls judge the presence of a central low-contrast element flanked by collinear or orthogonal high-contrast elements.   The display (target+flankers) was scaled in size to produce a lower and higher spatial frequency ("SF") condition (4 and 10 cycles/deg, respectively).  Larger stimulus arrays bias processing towards feedback connections from higher-order visual areas; smaller arrays bias processing towar

SUBMITTER: Keane BP 

PROVIDER: S-EPMC8750297 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature