Correlation of Somatostatin Receptor 1-5 Expression, [⁶⁸Ga]Ga-DOTANOC, [¹⁸F]F-FDG PET/CT and Clinical Outcome in a Prospective Cohort of Pancreatic Neuroendocrine Neoplasms.

ABSTRACT:

Purpose

The aim of this study was to correlate immunohistochemical (IHC) tissue levels of SSTR1-5 with the receptor density generated from [⁶⁸Ga]Ga-DOTANOC uptake in a prospective series of NF-PNENs.

Methods

Twenty-one patients with a total of thirty-five NF-PNEN-lesions and twenty-one histologically confirmed lymph node metastases (LN+) were included in this prospective study. Twenty patients were operated on, and one underwent endoscopic ultrasonography and core-needle biopsy. PET/CT with both [⁶⁸Ga]Ga-DOTANOC and [¹⁸F]F-FDG was performed on all patients. All histological samples were re-classified and IHC-stained with monoclonal SSTR1-5 antibodies and Ki-67 and correlated with [⁶⁸Ga]Ga-DOTANOC and [¹⁸F]F-FDG PET/CT.

SUBMITTER: Majala S 

PROVIDER: S-EPMC8750461 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature