Aging Aggravates Cachexia in Tumor-Bearing Mice.

ABSTRACT:

Background

Cancer is primarily a disease of high age in humans, yet most mouse studies on cancer cachexia are conducted using young adolescent mice. Given that metabolism and muscle function change with age, we hypothesized that aging may affect cachexia progression in mouse models.

Methods

We compare tumor and cachexia development in young and old mice of three different strains (C57BL/6J, C57BL/6N, BALB/c) and with two different tumor cell lines (Lewis Lung Cancer, Colon26). Tumor size, body and organ weights, fiber cross-sectional area, circulating cachexia biomarkers, and molecular markers of muscle atrophy and adipose tissue wasting are shown. We correlate inflammatory markers and body weight dependent on age in patients with cancer.

Results

We note fundamental d

SUBMITTER: Geppert J 

PROVIDER: S-EPMC8750471 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature