A Promising Treatment Strategy for Lung Cancer: A Combination of Radiotherapy and Immunotherapy.

ABSTRACT: Lung cancer is a leading cause of cancer-related deaths worldwide despite advances in treatment. In the past few decades, radiotherapy has achieved outstanding technical advances and is being widely used as a definitive, prophylactic, or palliative treatment of patients with lung cancer. The anti-tumor effects of radiotherapy are considered to result in DNA damage in cancer cells. Moreover, recent evidence has demonstrated another advantage of radiotherapy: the induction of anti-tumor immune responses, which play an essential role in cancer control. In contrast, radiotherapy induces an immunosuppressive response. These conflicting reactions after radiotherapy suggest that maximizing immune response to radiotherapy by combining immunotherapy has potential to achieve more effective anti-tumo

SUBMITTER: Miyasaka Y 

PROVIDER: S-EPMC8750493 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature