Pax-5 Protein Expression Is Regulated by Transcriptional 3'UTR Editing.

ABSTRACT: The Pax-5 gene encodes a transcription factor that is essential for B-cell commitment and maturation. However, Pax-5 deregulation is associated with various cancer lesions, notably hematopoietic cancers. Mechanistically, studies have characterized genetic alterations within the Pax-5 locus that result in either dominant oncogenic function or haploinsufficiency-inducing mutations leading to oncogenesis. Apart from these mutations, some examples of aberrant Pax-5 expression cannot be associated with genetic alterations. In the present study, we set out to elucidate potential alterations in post-transcriptional regulation of Pax-5 expression and establish that Pax-5 transcript editing represents an important means to aberrant expression. Upon the prof

SUBMITTER: Beauregard AP 

PROVIDER: S-EPMC8750734 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature