Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis.

ABSTRACT:

Background

Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis.

Methods

Up to 31,112 individuals of European descent were included in genome-wide association study (GWAS) meta-analyses of 47 circulating cytokines. Single nucleotide polymorphisms (SNPs) robustly associated with the cytokines, located in or close to their coding gene (cis), were used as instrumental variables. Inverse-variance weighted MR was used as the primary analysis, a

SUBMITTER: Bouras E 

PROVIDER: S-EPMC8750876 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature