Detection and analysis of long noncoding RNA expression profiles related to epithelial-mesenchymal transition in keloids.

ABSTRACT:

Background

The role of epithelial-mesenchymal transition (EMT) in the pathogenesis of keloids is currently raising increasing attention. Long noncoding RNAs (lncRNAs) govern a variety of biological processes, such as EMT, and their dysregulation is involved in many diseases including keloid disease. The aim of this study was to identify differentially expressed EMT-related lncRNAs in keloid tissues versus normal tissues and to interpret their functions.

Results

Eleven lncRNAs and 16 mRNAs associated with EMT were identified to have differential expression between keloid and normal skin tissues (fold change > 1.5, P < 0.05). Gene Ontology (GO) analysis showed that these differentially expressed mRNAs functioned in the extracellular matrix, protein binding, the positive regula

SUBMITTER: Chen Z 

PROVIDER: S-EPMC8751032 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature