MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer.

ABSTRACT:

Background

The long non-coding RNA (lncRNA), MALAT1, plays a key role in the development of different cancers, and its expression is associated with worse prognosis in patients. However, its mechanism of action and its regulation are not well known in prostate cancer (PCa). A general mechanism of action of lncRNAs is their interaction with other epigenetic regulators including microRNAs (miRNAs).

Methods

Using lentiviral stable miRNA transfection together with cell biology functional assays and gene expression/target analysis, we investigated the interaction between MALAT1 and miR-423-5p, defined as a target with in silico prediction analysis, in PCa.

Results

Through bioinformatic analysis of data available from TCGA, we have found that MALAT1 expression correlates wi

SUBMITTER: Ferri C 

PROVIDER: S-EPMC8751098 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature