Distinct Molecular Signatures of Aging in Healthy and HIV-Infected Individuals.

ABSTRACT:

Background

Virally suppressed chronic HIV-infected individuals on antiretroviral therapy experience similar immune impairments as HIV-uninfected elderly. However, they manifest symptoms of premature immune aging such as suboptimal responses to vaccination at a younger age. Mechanisms underlying premature immune aging are unclear.

Setting

The study site was University of Miami Miller School of Medicine.

Methods

In this study, we aimed to identify molecular signatures of aging in HIV-infected (HIV) individuals compared with age-matched healthy control (HC) participants. Transcriptomic profiles of peripheral blood mononuclear cells collected cross-sectionally from study participants were evaluated using RNA sequencing, and genes and pathways associated with age and HIV s

SUBMITTER: Rinaldi S 

PROVIDER: S-EPMC8751284 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature