Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults.

ABSTRACT:

Background

People living with HIV (PLWH) are disproportionately burdened with multimorbidity and decline in physiologic function compared with their uninfected counterparts, but biological mechanisms that differentially contribute to the decline in muscle function in PLWH compared with uninfected people remain understudied.

Setting

The study site was Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Methods

We evaluated skeletal muscle tissue for levels of total nicotinamide adenine dinucleotide (NAD), NAD+, and nicotinamide adenine dinucleotide (NADH) in middle-aged asymptomatic PLWH, coinfected with hepatitis C virus and/or cytomegalovirus and compared them with uninfected control participants.

Results

Of the 54 persons with muscle biopsy data

SUBMITTER: Tran T 

PROVIDER: S-EPMC8751286 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature